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Simvastatin enhances bone formation around titanium implants in rat tibiae

Identifieur interne : 005028 ( Main/Exploration ); précédent : 005027; suivant : 005029

Simvastatin enhances bone formation around titanium implants in rat tibiae

Auteurs : Y. Ayukawa [Japon] ; Y. Ogino [Japon] ; Y. Moriyama [Japon] ; I. Atsuta [Japon] ; Y. Jinno [Japon] ; M. Kihara [Japon] ; Y. Tsukiyama [Japon] ; K. Koyano [Japon]

Source :

Journal of Oral Rehabilitation [ 0305-182X ] ; 2010-02.

RBID : ISTEX:82102F63748135EC256B173954AF8DCED02332E6

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Wicri :
- topic : Titane.

English descriptors

Abstract

Summary Statins are cholesterol‐lowering drugs that have been reported to promote bone formation. The purpose of this study was to investigate the effect of simvastatin on the enhancement of bone formation around titanium implants. Thirty‐week‐old female rats received pure titanium implants in both tibiae. The animals were intra‐peritoneally administered 0, 0·125, 1, 5 or 10 mg kg−1 of simvastatin daily. After 30 days, the animals were sacrificed, and specimens were prepared. The bone contact ratio of the implant, bone density in the medullary canal and percentage of cortical bone were obtained. Markers for bone turnover were also measured using sera collected at the time of euthanasia. In the medullary canal, a scanty amount of bone was observed in the 0, 0·125 and 1 mg kg−1 groups. In contrast, in both the 5 and 10 mg kg−1 groups, thicker bone trabeculae were abundant. Histometric observations showed that the bone contact ratio and the bone density of both groups were significantly greater than those of the other groups (anova, P < 0·01). However, no significant difference in the percentage of cortical bone was found between groups. Serum chemistry showed that statin increased bone formation markers and decreased bone resorption markers. In conclusion, although the dose equivalent to that used in human patients with hypercholesterolemia was not effective, a simvastatin dose of 5 mg kg−1 or higher increased medullary bone formation around the titanium. In contrast, no effect of simvastatin on pre‐existing cortical bone was indicated.

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https://api.istex.fr/document/82102F63748135EC256B173954AF8DCED02332E6/fulltext/pdf

DOI: 10.1111/j.1365-2842.2009.02011.x

Affiliations:

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<series><title level="j" type="main">Journal of Oral Rehabilitation</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Ayukawa</term>
<term>Blackwell publishing</term>
<term>Bone contact ratio</term>
<term>Bone density</term>
<term>Bone formation</term>
<term>Bone healing</term>
<term>Bone trabeculae</term>
<term>Bone turnover</term>
<term>Calcif tissue</term>
<term>Canal</term>
<term>Control group</term>
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<term>Cortical bone</term>
<term>Cortical bone area</term>
<term>Direct contact</term>
<term>Experimental groups</term>
<term>Female rats</term>
<term>Histological</term>
<term>Histological appearance</term>
<term>Implant</term>
<term>Journal compilation</term>
<term>Kyushu university</term>
<term>Medullary</term>
<term>Medullary canal</term>
<term>Mevalonate pathway</term>
<term>Oral rehabilitation</term>
<term>Osteoblast</term>
<term>Osteoclast</term>
<term>Osteogenesis</term>
<term>Pathway</term>
<term>Present study</term>
<term>Previous study</term>
<term>Serum chemistry</term>
<term>Simvastatin</term>
<term>Simvastatin administration</term>
<term>Small gtpases</term>
<term>Statin</term>
<term>Systemic application</term>
<term>Tibia</term>
<term>Tissue layer</term>
<term>Titanium</term>
<term>Titanium implant</term>
<term>Titanium implants</term>
<term>Toluidine</term>
<term>Trabecular</term>
<term>White rectangle</term>
<term>Wound healing</term>
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<term>Cortical bone area</term>
<term>Direct contact</term>
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<term>Histological</term>
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<term>Journal compilation</term>
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<front><div type="abstract">Summary  Statins are cholesterol‐lowering drugs that have been reported to promote bone formation. The purpose of this study was to investigate the effect of simvastatin on the enhancement of bone formation around titanium implants. Thirty‐week‐old female rats received pure titanium implants in both tibiae. The animals were intra‐peritoneally administered 0, 0·125, 1, 5 or 10 mg kg−1 of simvastatin daily. After 30 days, the animals were sacrificed, and specimens were prepared. The bone contact ratio of the implant, bone density in the medullary canal and percentage of cortical bone were obtained. Markers for bone turnover were also measured using sera collected at the time of euthanasia. In the medullary canal, a scanty amount of bone was observed in the 0, 0·125 and 1 mg kg−1 groups. In contrast, in both the 5 and 10 mg kg−1 groups, thicker bone trabeculae were abundant. Histometric observations showed that the bone contact ratio and the bone density of both groups were significantly greater than those of the other groups (anova, P < 0·01). However, no significant difference in the percentage of cortical bone was found between groups. Serum chemistry showed that statin increased bone formation markers and decreased bone resorption markers. In conclusion, although the dose equivalent to that used in human patients with hypercholesterolemia was not effective, a simvastatin dose of 5 mg kg−1 or higher increased medullary bone formation around the titanium. In contrast, no effect of simvastatin on pre‐existing cortical bone was indicated.</div>
</front>
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Simvastatin enhances bone formation around titanium implants in rat tibiae

Simvastatin enhances bone formation around titanium implants in rat tibiae

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri